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General Studies 3 >> Science & Technology

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MICROBIOME

MICROBIOME

 
1. Context
According to an assessment published in Nature Biotechnology "With the claim that the microbes in our bodies outnumber our own cells 10 to one"
 
2. What is a microbe?
 
A microbe, short for a microorganism, is a microscopic organism that is too small to be seen with the naked eye. Microbes are diverse and encompass a wide range of life forms, including bacteria, archaea, viruses, fungi, and some microscopic eukaryotic organisms like protozoa and microalgae

Here's a brief overview of the main types of microbes:

  1. Bacteria: Bacteria are single-celled organisms that are among the most abundant and diverse life forms on Earth. They have a simple cellular structure without a true nucleus and are found in a variety of environments, including soil, water, the human body, and extreme habitats like hot springs and deep-sea vents. Some bacteria are beneficial, playing essential roles in processes such as nutrient cycling, while others can be pathogenic and cause diseases.

  2. Archaea: Archaea are another group of single-celled microorganisms that resemble bacteria but are genetically and biochemically distinct. They are often found in extreme environments like acidic hot springs and hydrothermal vents. Some archaea are also found in more moderate environments, including the human gut.

  3. Viruses: Viruses are unique microbes that are not considered living organisms in the traditional sense because they cannot carry out metabolic processes on their own. Instead, viruses infect host cells and hijack their machinery to replicate. They can infect a wide range of hosts, including animals, plants, and bacteria, causing various diseases.

  4. Fungi: Fungi are eukaryotic microorganisms that include molds, yeasts, and mushrooms. While some fungi are beneficial, such as those used in the production of food and medicine, others can be pathogens that cause infections in humans, animals, and plants.

  5. Protozoa: Protozoa are single-celled eukaryotic microorganisms that are often found in aquatic environments. Some protozoa are free-living, while others are parasitic and can cause diseases like malaria and amoebic dysentery.

  6. Microalgae: Microalgae are microscopic photosynthetic organisms that can be found in aquatic environments. They are essential for producing oxygen and are a primary food source for many aquatic organisms. Some microalgae are also used in biotechnology and biofuel production.

3. Microbiome
 
Microbiota medicine: towards clinical revolution | Journal of Translational  Medicine | Full Text
  • The microbiome refers to the collection of microorganisms, including bacteria, viruses, fungi, and other microbes, that inhabit a particular environment or organism.
  • Microbiomes can be found in various places, including the human body, soil, water, plants, and animals. One of the most extensively studied microbiomes is the human microbiome, which consists of the trillions of microorganisms living in and on the human body.
  • The human microbiome plays a crucial role in human health. It has been linked to various functions, including digestion, the immune system, and even mental health.
  • The gut microbiome, in particular, has received a lot of attention for its role in digestion and overall well-being.
  • The microbiome can influence how our bodies digest and absorb nutrients from food.
  • Certain bacteria in the gut, for instance, can help break down complex carbohydrates and produce vitamins
  •  Research on the microbiome has led to various applications in medicine, agriculture, and environmental science.
  • For example, probiotics and prebiotics are used to promote a healthy gut microbiome. In agriculture, understanding soil microbiomes can improve crop yields and reduce the need for chemical fertilizers
  • Microbiomes are not limited to humans and animals. They also play essential roles in ecosystems.
  • For example, soil microbiomes are critical for nutrient cycling and plant health, and aquatic microbiomes can affect water quality
  • Contrary to some opinions, mother don't pass microbiomes to child at birth, Some microorganisms are directly transferred during birth but they constitute a small fraction of the human microbiota and only an even smaller fraction of these microbes survive and persist throughout the child's life
4.Are microbiomes are dangerous?

Microbiomes themselves are not inherently dangerous; in fact, they are essential for life on Earth and play many beneficial roles in various ecosystems and in the bodies of living organisms. Microbiomes consist of diverse communities of microorganisms, including bacteria, archaea, viruses, fungi, and other microbes, and they are present in numerous environments, including the human body, soil, water, and more.

Here are some important points to consider:

  1. Beneficial Roles: Microbiomes are involved in crucial processes such as nutrient cycling, decomposition of organic matter, and maintaining ecosystem balance. In the human body, the microbiome plays a role in digestion, the development of the immune system, and the production of certain vitamins.

  2. Human Health: The human microbiome, particularly the gut microbiome, is linked to various aspects of human health. A balanced and diverse gut microbiome can support digestion, protect against pathogens, and contribute to overall well-being.

  3. Disease: While microbiomes themselves are not dangerous, imbalances or disruptions in microbiomes, known as dysbiosis, can be associated with health issues. For example, an overgrowth of harmful bacteria in the gut can lead to gastrointestinal problems. Certain infections are caused by pathogenic microorganisms.

  4. Pathogens: Some microorganisms within microbiomes can be pathogenic and cause diseases. However, these pathogenic microorganisms are typically a small subset of the overall microbiome and are not representative of the entire microbial community.

  5. Beneficial Microbes: Many microbes within microbiomes are beneficial and can even be used in various applications. Probiotics, for instance, are live bacteria and yeasts that are often included in foods and supplements to promote health.

5.Probiotics

Probiotics are live microorganisms that are believed to provide health benefits when consumed in adequate amounts. These microorganisms, typically bacteria or yeasts, are similar to the beneficial microorganisms naturally found in the human gut and other parts of the body. Probiotics are often referred to as "good" or "friendly" bacteria.

Here are some key points about probiotics:

  1. Types of Probiotics: Probiotics encompass a variety of bacterial strains, with the most common belonging to the genera Lactobacillus and Bifidobacterium. Certain yeasts, such as Saccharomyces boulardii, are also considered probiotics.

  2. Sources: Probiotics can be found naturally in some fermented foods, including yogurt, kefir, sauerkraut, kimchi, miso, and certain cheeses. They are also available in the form of dietary supplements, such as capsules, tablets, powders, and liquids.

  3. Health Benefits: Probiotics are associated with several potential health benefits, including:

    • Digestive Health: Probiotics can help maintain a healthy balance of gut bacteria, potentially improving digestion and reducing symptoms of conditions like irritable bowel syndrome (IBS) and diarrhea.
    • Immune Support: Some probiotic strains may enhance the immune system's function and help protect against infections.
    • Vaginal Health: Certain probiotics are used to promote vaginal health by maintaining a balanced vaginal microbiome.
    • Oral Health: Probiotics are being studied for their potential role in promoting oral health by reducing the growth of harmful bacteria in the mouth.
  4. Probiotics and Microbiome: Probiotics can influence the composition and diversity of the gut microbiome, which plays a crucial role in overall health. They may help restore microbial balance in cases where the microbiome is disrupted, such as after antibiotic use.

 
6.Way forward
The establishment of a healthy microbiome in early life is crucial for a child's overall health and immune system development. Disruptions in this process, such as through the use of antibiotics during pregnancy or early infancy, cesarean section delivery (which reduces exposure to vaginal microbes), or not breastfeeding, can have implications for the composition of the child's microbiome and potentially impact their susceptibility to certain health conditions.
 
 
For Prelims: Microbes, Microbiomes, Probiotics
For Mains: 1.Explain the concept of microbiomes and their significance in human health and ecology. Provide examples to illustrate your points
2.Discuss the role of the human gut microbiome in digestion, immunity, and overall well-being. How can disruptions in the gut microbiome lead to health issues?
 
Previous Year Questions
1.Consider the following statements in respect of probiotics : (UPSC CSE 2022)
1. Probiotics are made of both bacteria and yeast.
2. The organisms in probiotics are found in foods we ingest but they do not naturally occur in our gut.
3. Probiotics help in the digestion of milk sugars.
Which of the statements given above is/are correct?
A. 1 Only
B.2 Only
C. 1 and 3
D.2 and 3
 
Answer (C)
 
Source: The Hindu

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