ANTIBIOTIC RESISTANCE

1. Context

Antibiotics were introduced to the world in the mid-20th century, and deaths attributable to infections dropped from over 50% to 10-15%. Experts have been warning for decades that the threat of antibiotic resistance could take us back in time to when even simple infections were deadly.

2. A Study on infectios: Outcome

A study in 2019 found more than 1 million people a year died from infections linked to microbes that are resistant to antibiotics -more than those who died due to malaria or HIV/AIDS.
Experts describe antibiotic resistance as one of the greatest challenges facing humanity. They predict that if the problem remains unsolved, 10 million people could die as a result by 2050.
Maintaining modern medicine and standards of health in the way we know them today will depend on the development of new antibiotic drugs.

3. What causes Antibiotic Resistance?

Antibiotic resistance occurs when bacteria evolve to evade antibiotics. Overuse and misuse of antibiotics are the biggest drivers of resistance. That means that the more we use antibiotics, the worse the problem of antibiotic resistance becomes.
Antibiotics work by binding to a specific target protein on a bacteria, then entering to kill it from the inside.
Penicillin, for example, weakens the bacterial cell wall, causing the cell to disintegrate.
The most common ways bacteria evade antibiotics come from mutations that allow them to stop drugs from binding to bacteria.
It’s like the bacteria changed the locks so the antibiotic key no longer opens the cell door.

4. The Problem of Antibiotic resistance is solved by two options

Antibiotic resistance will always be with us. It’s the nature of evolution by natural selection that means bacteria will always find ways to evade antibiotics. But experts are optimistic we can find ways to limit antibiotic resistance in the next decades, at least enough to stop the issue from spiraling into a bigger crisis.
Unfortunately, it isn’t as simple as developing a drug that will permanently overcome antibiotic resistance.
It’s an incredibly complex science, even more so than finding a vaccine for a virus such as COVID-19.
For one, there’s huge diversity among bacteria -not all drugs work on a given organism, and not all organisms are killed by a given drug.

4.1 Option 1:Modify existing antibiotics
Scientists have been working on the issue from many different angles. One approach is to modify old antibiotics so they overcome resistance.

Toxicity is the ability of a substance to have a poisonous effect and either cause harm or death.

4.2 Option 2: Develop new antibiotics
Another strategy is to make brand-new drugs, but this approach hasn’t been very successful in recent decades.

5. New Innovations

“In silico” refers to experiments performed via computer simulation.
These innovations are helping scientists overcome older challenges in drug discovery.
The hope is that antibiotic-resistant drugs can be pushed through drug development pipelines quickly enough for them to make an impact in global health care.
But central to the issue is that antibiotic resistance develops quickly whereas antimicrobials- the basis of antibiotic drugs- are developed slowly. Scientists hear the clock ever ticking.

6. Lack of global support against Antibiotic resistance

As with the race for Covid-19 vaccines, overcoming antibiotic resistance will require tremendous international effort dedicated to the problem. But that's exactly what's missing.
Reports indicate there were 43 antibiotics in clinical trials or pending approval in December 2020. For comparison, over 1,300 anticancer agents were at similar stages of development.
Many of the issues here came from the commercialization of drug development.
Some large companies have given up their antibiotics programs based on commercial considerations and several small companies developing new antibiotics have failed financially before their candidates reached the clinic.
We need more investment in all antibiotic discovery strategies.

7. Need for the regulation of antibiotics

In the short term, some experts want more regulation of antibiotics so their use is limited to situations when they are strictly necessary.
The hope is this will buy us some time to slow down antibiotic resistance while drug discovery catches up.
Antibiotics are not well-regulated in many parts of the world. For example, antibiotics were “flying off the shelves” during the COVID-19 pandemic in India, where people can buy them over the counter in pharmacies.
Limiting the use of antibiotics in agriculture would also have a major impact, experts say.
The EU and US have banned the use of antibiotics for livestock growth, and in 2022, the EU brought in legislation to prohibit all forms of routine antibiotic use in farming.

For Prelims & Mains

For Prelims: Malaria, HIV/AIDS, COVID-19, Antibiotic Resistance, bacterial cell wall, European Union(EU), anticancer agents, and Penicillin.

For Mains: 1. What are antibiotics and how the problem of antibiotic resistance is solved? Discuss the need to regulate antibiotics in India.

Source: The Indian Express

Share to Social

UPSC Article