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General Studies 3 >> Science & Technology

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NAEGLERIA FLOWERI

NAEGLERIA FLOWERI

 
 
1. Context
A five-year-old girl undergoing treatment for primary amoebic meningoencephalitis (PAM), a rare infection caused by Naegleria fowleri or “brain-eating amoeba”, died at the Government Medical College Hospital in Kozhikode 
 
 
2. What is primary amoebic meningoencephalitis?
 
Primary amebic meningoencephalitis (PAM) is a rare and severe brain infection caused by the amoeba Naegleria fowleri, a free-living single-celled organism. Naegleria fowleri thrives in warm freshwater and soil globally and infects individuals through the nasal passages. It grows best at higher temperatures, up to 115°F (46°C), and can briefly survive in warm conditions. This amoeba is typically found in warm freshwater bodies such as lakes, rivers, and inadequately maintained or under-chlorinated recreational water sites, including swimming pools, splash pads, and surf parks
 
3. How does Naegleria fowleri infect people?

Naegleria fowleri typically enters the body through the nose, often when individuals are swimming. It then moves to the brain, where it damages brain tissue and causes swelling.

In a recent case in Kozhikode, it is suspected that a girl contracted the infection while swimming in a local river on May 1, along with four other children who did not develop symptoms and tested negative. It is important to note that Naegleria fowleri infection cannot occur from drinking contaminated water, and primary amebic meningoencephalitis (PAM) is not contagious

4. Symptoms and Treatment

Primary amoebic meningoencephalitis (PAM) is a rare and often fatal brain infection caused by the amoeba Naegleria fowleri. The symptoms of PAM typically appear within one to nine days after exposure, with an average onset of about five days. The symptoms progress rapidly and can be divided into early and later stages:

Early Symptoms

Early symptoms often resemble those of bacterial meningitis and may include:

  • Severe frontal headache
  • Fever
  • Nausea
  • Vomiting

Later Symptoms

As the infection progresses, more severe symptoms can develop, such as:

  • Stiff neck
  • Confusion
  • Lack of attention to people and surroundings
  • Loss of balance
  • Seizures
  • Hallucinations
  • Altered mental status
  • Sensitivity to light

Treatment

Early detection and treatment are crucial for improving the chances of survival, though the prognosis for PAM is generally poor due to the rapid progression of the disease.

If PAM is suspected, immediate medical attention and treatment are essential. The standard treatment typically involves a combination of antifungal and antimicrobial drugs, including amphotericin B, rifampin, and miltefosine, among others. However, due to the rarity and severity of the infection, effective treatment options are limited, and prevention through avoiding exposure to contaminated water is critical

5. Way Forward

There have been 20 reported cases of PAM in India, with the Kozhikode case being the seventh such infection in Kerala. In July 2023, a 15-year-old boy died of it in Alappuzha. The first incident in Kerala was also reported in Alappuzha in 2016, perhaps due to the large number of water bodies here. Since then, infections have been reported in Malappuram, Kozhikode and Thrissur

 

Source: Indianexpress


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